The Most Toxic Build in Megabonk: Poison, Cheese, and Chaos

In the chaotic world of Megabonk—a roguelike where you crush endless waves of enemies and stack crazy power-ups—one build stands out for its pure, nasty effectiveness: the ultimate poison setup with the Amog character.

This build turns the game into a toxic nightmare, using area-of-effect poison that spreads every time a poisoned enemy dies, all centered around the Poison Flask weapon.

Here’s our step-by-step look at the run, from a shaky start to overwhelming power, based entirely on our gameplay. We’ll show you how the build evolves, the key choices that make it work, and the game mechanics that make it so intense.

Our Gameplay

As we get into the thicker part of the stage, I zero in on our core strategy. The Poison Flask’s damage-over-time is perfect for bunched-up enemies—you can see the stacks climb, and it’s a beautiful thing.

My plan is simple: focus on weapon upgrades, luck, and experience gain to power up the flask fast. I ignore anything that doesn’t help, like pure evasion. A key find is the duplicator item, which I save for some cheesy power later. First, there’s a boss to handle. Using shields to soak hits, I weave around the arena, letting the poison explosions jump between the smaller enemies.

After the boss, I crack open chests hoping for that rare purple poison item. I don’t get it, but I do grab a perk that gives a 100% damage bonus after 1,000 kills—a slow burn that should pay off big later on.

I reluctantly pick up some movement speed to stay alive in tougher fights. Life steal from other items keeps me going, turning the build’s usual weakness—long battles—into a strength. When two bosses spawn at once (a rare event I usually avoid), I take one down for its luck bonus, keeping the difficulty in check while hunting for legendaries. I choose power-up drop chance over extra projectiles because more chests mean more shots at damage multipliers.

The real “aha!” moment comes when I see how blood mark works. Every tick of poison counts as a hit, setting off area-of-effect damage and insane life steal. I tested it right there, watching my health refill in the middle of a crowd. This broken interaction is what takes the build from good to toxic.

Early Game Grind: Building the Poison Foundation

As we get into the thicker part of the stage, I zero in on our core strategy. The Poison Flask’s damage-over-time is perfect for bunched-up enemies—you can see the stacks climb, and it’s a beautiful thing.

My plan is simple: focus on weapon upgrades, luck, and experience gain to power up the flask fast. I ignore anything that doesn’t help, like pure evasion.

A key find is the duplicator item, which I save for some cheesy power later. First, there’s a boss to handle. Using shields to soak hits, I weave around the arena, letting the poison explosions jump between the smaller enemies.

After the boss, I crack open chests hoping for that rare purple poison item. I don’t get it, but I do grab a perk that gives a 100% damage bonus after 1,000 kills—a slow burn that should pay off big later on.

I reluctantly pick up some movement speed to stay alive in tougher fights. Life steal from other items keeps me going, turning the build’s usual weakness—long battles—into a strength. When two bosses spawn at once (a rare event I usually avoid), I take one down for its luck bonus, keeping the difficulty in check while hunting for legendaries. I choose power-up drop chance over extra projectiles because more chests mean more shots at damage multipliers.

The real “aha!” moment comes when I see how blood mark works. Every tick of poison counts as a hit, setting off area-of-effect damage and insane life steal. I tested it right there, watching my health refill in the middle of a crowd. This broken interaction is what takes the build from good to toxic.

Mid-Game Power Spikes: Stacking Cheese and Synergies

Deeper in the Forest, I focus on farming experience to max out the flask. I grab every free chest, using credit cards that give a 7.5% damage boost per chest opened—and these stack together beautifully. My luck spikes, pulling purples like bonus projectiles for better shield coverage.

I start banishing weak legendaries to clean up the item pool I can get later. Damage numbers jump around but average a solid 94 per hit, with poison wiping out entire rows of enemies.

I face a big 31,000 HP boss shrine, setting up to maximize poison explosions, though some enemies get stuck on different levels. I skip a few fights to save time, trusting the build’s scaling to handle elites later. More chests give stat boosts, and I stack poison duration so it lasts longer.

Shrines promise purple items, but the randomness can be frustrating. I duplicate a powerful cheese item again, risking some critical hit chance, because the chance for multiple poison ticks is too good to pass up.

Getting to stage two is a personal best for me in hardcore mode. A gas mask drops, giving armor and life steal for each poisoned enemy—a perfect fit. I really wanted a specific dagger for an execute effect, but took gold instead to buy more chests. I enlarge the poison explosions to survive tight spots.

I even pass up an amazing item (the wrench) for more pickup range, because I need to grab experience shards from a safe distance. I stack moldy cheeses until every hit has a huge chance to poison.

Tough waves roll in, but poison auras near walls handle bosses. HP regeneration and healing items keep me in the fight. My credit card multipliers climb, and with eleven cheeses, my poison trigger chance is through the roof.

I use an anvil to guarantee damage upgrades on future legendaries. Attack speed makes the poison tick faster, and my pickup range gets so good it feels legendary.

Late-Game Challenges: Boss Fights and Endless Ambitions

A massive swarm wave shows a weak spot—I still need more direct damage upgrades, so I grab experience while my shields fail. Magnets pull in loot, critical hits keep my damage steady, and I bulk up my health. I open chests carefully, spreading poison where it’s needed most.

Then, the endless portal opens. I wait for purple items, farming experience shards. I use walls and golems for cover. My final goal is to max the flask: damage, luck, critical hit chance. The last boss is a 7-minute marathon where I shoot through walls, using stone golems to spread poison vertically.

I add difficulty tomes to spawn more elites, but only for the experience. Fast elites are annoying, but watching golems die on top of towers never gets old. I get another gas mask, great for stacking defenses, though it’s less useful for single targets. I never found that execute dagger I wanted, which was a letdown. I rely on jumps to dodge and life steal to survive.

My goal was a 5-minute endless run, but I fall just short. Hot waves start spawning early, and portals can push you into danger. I level up like crazy, skipping recording breaks to keep the run alive.

I use bombs to clear groups, and boost my critical damage to make up for my lacking base damage. Wrench items help by converting other stats into raw power.

The Toxic Climax: Pushing Limits and Reflections

In the end, I gambled on experience over safety. The build hit its peak: over 1,000 poison damage, eleven stacked cheeses, and gas masks piling on armor. I didn’t max everything, but this was my farthest run ever.

This run shows what makes this game so addictive. The poison build became a mass powerhouse, even if it was a bit slow on single bosses. We pushed it to its toxic limit, thriving in the chaos right until the very end.